Abstract Search

ea0029p8 | Adrenal cortex | ICEECE2012

Defining 17α-hydroxylase in zebrafish: expression pattern of two paralog genes (zCyp17a1; zCyp17a2) and comparative in vitro and in silico analysis

Parajes S. , Griffin A. , Miguel Escalada I. , Rose I. , Taylor A. , Sacco L. , Grotzinger J. , Arlt W. , Mueller F. , Krone N.

Background: Zebrafish is emerging as a comprehensive model system in endocrinology. Zebrafish synthesise steroid hormones in the interrenal (counterpart of the mammalian adrenal), gonad and brain. Data on steroidogenic pathways is patchy and steroidogenic enzymes in zebrafish have not been well characterised. Human 17α-hydroxylase (hCYP17A1) facilitates two conversion steps, 17α-hydroxylase and 17,20-lyase reactions in the adrenal and gonad. Two zCyp17a (zCyp17a1; zC...

0 shares

Endocrine Abstracts

Defining 17α-hydroxylase in zebrafish: expression pattern of two paralog genes (zCyp17a1; zCyp17a2) and comparative in vitro and in silico analysis

BiosciAbstracts